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FIGURE 7 The strong role of severe oxidative stress, reduced antioxidant defenses like GSH with increased lipid peroxidation and malondialdehyde generation (213), lipid, protein and DNA oxidation with increased apoptosis and necrosis in atherosclerosis as a major cause of cardiovascular diseases and stroke, supports the use of complementary and alternative medicines, dietary supplements, and antioxidants with hardly any adverse effect, able to restore homeostasis reversing oxidative stress (214)
For example, high glucose levels were discovered to directly increase the expression levels of LOX and its subsequent enzymatic activation in the dermis or endothelial layer, which resulted in excessive crosslinking and disruption in the formation of collagen fibrils and hindered ECM integrity (80)
Many patients reported that two Botox treatments reduced their number of migraine days by almost 50%
